1. Use wide ad formats. Many publishers find the 728x90 Leaderboard outperforms the 468x60 banner by about 70%. I particularly recommend using the 728x90 Leaderboard, 160x600 Wide Skyscraper, and 300x250 Medium Rectangle.
2. Embed Google ads in your content, and place Google ads at the end of your articles, news stories and reviews. Placing a 468x60 Banner in the typical slot at the top of page, or a 120x600 Skyscraper along the right-hand side of page, work well for cost-per-thousand impressions (CPM) ads. However, for cost-per-click (CPC) contextual advertising, AdSense tends to work best when integrated with your content.
3. Blend your ad colours into your website. After running a test with a bright pink 728x90 Leaderboard on a black background, I learned that complementary colours often work better. Try blending the background and borders of your ads into your site, and use a text colour that stands out but already exists on your site. Blending decreases ad blindness and users are more likely to notice ads that interest them.